High-throughput assessment of genome edited cells with Tapestri antibody hashing

Genome editing, in which precise changes can be made to the genome, has opened the door to vast opportunities in areas such as cell and gene therapy development, functional genomics, and disease modeling.

Mission Bio’s Tapestri® Genome Editing (GE) solution has introduced a robust method for high-throughput analysis of genomic edits at single-cell resolution. The GE solution analyzes both insertions/deletions (indels) and single nucleotide variants (SNVs), providing precise data for on- and off-target edit frequencies, edit zygosity, and co-occurrence. Here we introduce a new capability, sample multiplexing by antibody hashing to Tapestri while highlighting the power of the GE solution. The combination of these two innovative solutions creates an indispensable tool that equips researchers to unravel the intricacies of genome editing outcomes at a reduced per-sample price.