Tools for every stage of your single-cell experiments

Web-based panel design built on an optimized algorithm for our chemistry.

Tapestri Designer makes it simple to build a panel for any single-cell DNA and RNA experiment — from a focused 50-target hotspot panel to a 1,000-amplicon discovery panel.

Capabilities:

• Design custom panels from 1 to 1,000 amplicons
• Target SNPs, on- and off-target edits and copy number variants
• Submit your own target list, or select from the Mission Bio catalog offerings
• Design panels for human, mouse, or any custom reference genome
• Review coverage summaries and in silico QC metrics before ordering

Launch Tapestri Designer →

Cloud-based secondary analysis — from FASTQ to single-cell output, with no local infrastructure required.

Tapestri Pipeline is Mission Bio's cloud-based bioinformatics software that processes sequencing data generated from the Tapestri platform. Upload FASTQ files, and the pipeline returns a complete run QC report alongside single-cell output files (.h5, VCF, and HTML reports) ready for downstream interpretation.

Capabilities:

• Import FASTQ files from local computer, Amazon S3, or Illumina BaseSpace
• Process bulk samples to generate genotype demultiplexing files
• Demultiplex up to 3 samples per run using genotype-based or antibody-hashing approaches
• Process DNA only or DNA + Protein data
• Generate .h5 files for downstream use in Mosaic, VCF files and BAM files

Output: An automated interactive QC report with summary performance metrics and single-cell output files

Automated analysis combining secondary and tertiary processing into a single step, generating easy-to-interpret reports. No bioinformatics expertise required.

Clonal Insights

A fully automated solution for resolving clonal architecture in heterogeneous samples — combining DNA variant calling, surface protein signatures, and (now) gene expression. Ideal for detecting rare leukemic clones based on pathogenic mutations that can predict disease state and progression.

Now available with DNA + RNA support for integrated genotype, immunophenotype, and gene expression at single-cell resolution.

Capabilities:

• Genotype-based sample demultiplexing (up to 3 samples)
• Known and de novo variant calling
• Gene expression profiling (DNA + RNA)
• Clone and phylogeny construction
• Per-clone variant lists and protein signatures
• Time course analysis with fish plots and side-by-side clone comparison

Output: A comprehensive, automated report including clonal summaries, detailed variant calls, protein signatures, phylogenetic trees, and longitudinal clone evolution.

[See sample data →]

Single-cell characterization of on- and off-target editing.

Bulk sequencing mixes DNA across cells, so a 50% VAF could mean half the cells were perfectly edited — or that every cell was imperfectly edited. The Genome Editing Pipeline resolves the difference at the single-cell level, capturing the full spectrum of editing outcomes including rare and off-target events.

Capabilities:

• Distinguish mono-allelic and bi-allelic edits in every cell
• Quantify intended edits, predicted off-targets, and their co-occurrence within the same cell
• Capture rare events including predicted translocations between on- and off-target sites
• Correlate specific edits with functional surface protein loss in the same cell
• Works with knockout (NHEJ) and base editing

Output: A comprehensive, automated report covering top on- and off-target edits, top edit combinations, zygosity, and predicted translocations.

Learn more about Genome Editing applications →

Genome-wide CNV measurement at single-cell resolution.

Designed for cell and gene therapy product characterization, oncology research, and any application where chromosomal stability matters. Use with the catalog Genome-Wide CNV panel or your own custom design.

Capabilities:

• Genome-wide coverage with our 500-amplicon catalog panel, ~5.8 Mb average spacing across nearly the entire genome
• 5–15 Mb resolution, comparable to G-banding
• Genome-wide CNV alongside custom targets such as genome edits, SNVs, or focal CNVs in the same assay
• Combine CNV with cell-surface protein markers (DNA + Protein)
• Software defines clones by CNV aberrations and quantifies clonal heterogeneity across the genome

Output: An automated and comprehensive report with insights into focal and large CNVs across the whole genome.

Learn more about Genome Integrity →

Rare clone detection optimized for plasma cell neoplasms.

Purpose-built for the heterogeneity of Multiple Myeloma, MGUS, and SMM samples — where rare pathogenic clones drive progression and relapse. This pipeline generates our most comprehensive report including variant, VDJ, CNV and protein analysis. Use with our catalog Multiple Myeloma panel or your own custom design.

Capabilities:

• Genotype-based sample demultiplexing (up to 3 samples)
• Known and de novo variant calling
• Clone and phylogeny construction
• Per clone variant lists and protein signatures
• VDJ clonotyping
• Copy number analysis across the entire panel
• Time course analysis with fish plots and side-by-side clone metric comparison

Output: Automated, easy-to-interpret reports with clonal insights, VDJ clonotyping, protein signatures, copy number estimation, phylogenetic trees, and longitudinal clone evolution.

Learn more about Multiple Myeloma applications →