Single-cell Sequencing 101: DNA & multi-omics for precision medicine

Cancer is a complex disease that continuously evolves in response to environmental pressures. The dynamism and heterogeneity of tumors have significant clinical implications. In this eBook, review how single-cell DNA sequencing and multi-omics are used to dissect clonal architecture, providing valuable insights for clinical strategies, disease modeling, and the development of cell and gene therapies.

Specifically, we cover:

• The clonal evolution of cancer
• Linking genotype & phenotype with multi-omics
• Translational applications for the clinic
• Single-cell analysis of genome engineering