Single-Cell Cohort Analysis

This technical brochure introduces Mission Bio’s Single-Cell Cohort Analysis module, a bioinformatic solution designed to provide deeper insights into the clonal dynamics affecting disease progression and therapeutic resistance. Optimized for large-scale, multiomic datasets, the platform empowers researchers to move beyond single-sample analysis to track clonal evolution across patient populations and multiple timepoints.

By leveraging the Tapestri platform, researchers can correlate mutation-defined clones with prognostic protein expression profiles to uncover hidden pathogenic variants that are often missed by single-analyte methods like bulk NGS or flow cytometry. The brochure details a comprehensive cohort analysis pipeline that visualizes complex clonal architecture, focal CNV, and structural variants through intuitive heatmaps. Freely hosted on the Mosaic single-cell analysis suite via GitHub, this tool is essential for evaluating therapeutic efficacy and making precise clinical research decisions.

Features:

• Clonal Tracking: Monitor clonal evolution and treatment response across various timepoints.
• Multiomic Correlation: Link mutation-defined clones directly to prognostic protein expression.
• Comprehensive Visualization: Generate heatmaps for VDJ clonotypes, structural variants, and focal CNV.
• Open Access: Module is available freely through the Mosaic single-cell analysis suite.