Expanding biology with single cell multiomics: Experimental and computational approaches

Linking genetic variation to cellular function remains a core challenge in biology. In this seminar, Mary Nguyen of Mission Bio will introduce the Tapestri Platform and demonstrate how targeted single-cell multiomic approaches spanning DNA, RNA, protein, and methylation enable direct mapping of genotype to phenotype within the same cell.

Through application-driven examples, the talk will highlight how integrated multiomic readouts can resolve clonal architecture, define functional consequences of somatic variation, and uncover cell state transitions obscured by bulk analysis. Key considerations for experimental design and generation of high-quality, analysis-ready datasets will also be discussed.

Attendees will learn how to:

• Resolve clonal heterogeneity and evolutionary dynamics
• Assess editing outcomes, zygosity, and functional impact in cell and gene therapy workflows
• Link genetic variants to transcriptional and epigenetic states
• Design targeted panels and analytical strategies for robust multiomic data integration

Details

DATE/TIME

Thursday May 14, 2026

12:00pm - 1:00pm

LOCATION

Gladstone Institutes

Room 107 C/D