Single-cell DNA sequencing resolves the genetic complexity underlying CLL progression

Co-occurrence and zygosity of mutations in subclonal populations are frequently missed with bulk sequencing. In high-count monoclonal B-cell lymphocytosis (MBL), these mutations were detectable across all patient samples, on average 41 months prior to chronic lymphocytic leukemia (CLL) progression as a result of single-cell analysis. Learn how the Tapestri Single-cell DNA CLL Panel was used to both gain further insights into patient samples and correlated with a deep targeted sequencing approach.